In ccRCC, patients with higher nuclear HIF-1α (P = 0.002) and HIF-3α (P = 0.019) (> median value) expression levels had significantly shorter survival than those with lower levels (< median value) and cancer-specific survival (CSS), whereas nuclear HIF-2α expression (P = 0.12) had no association with CSS. This evidence concerns the gene EPAS1 and nonpapillary renal cell carcinoma.