An additional ceRNA affecting firmly TGF-β signaling is LOC646329-variant D, whose overexpression suppressed CRC progression through sponging miR-29b-1, which is harbored at the third intron of LOC646329, followed by the upregulation of SMAD3 and p21 levels, while cyclinD1 was downregulated, shifting a high percent of the CRC cell population to the G1 phase (77). This evidence concerns the gene SMAD3 and colorectal carcinoma.