Furthermore, the expression of the lncRNA CTBP1 divergent transcript (CTBP1-DT or CTBP1-AS2) was associated with worse overall survival of CRC patients and positively correlated with TGFB1, SMAD2, and SMAD3 in both colon and rectal adenocarcinoma patients (78). This evidence concerns the gene CTBP1 and rectum adenocarcinoma.