TGFB1 and non-small cell lung carcinoma: A very similar mechanism involves MIR4435-2HG that is highly expressed in NSCLC, which was bioinformatically predicted to sponge distinct miRNAs that can target the TGFB1 mRNA, thus indirectly enhancing TGF-β signaling that was required for lung cancer cell proliferation and migration (50).