TGFB1 and neoplasm: Cancer cell biological research and in vivo mouse models of cancer coupled to a large number of studies in cancer patients have suggested with a high degree of confidence that TGF-β is a suppressor of pre-malignant hyperplasia in many solid and hematopoietic tumors, but is also involved in the progression of tumors, especially during the stages of dissemination of tumor cells via local or distant invasion and metastasis (2).