Research suggests that age [2], gender, marital status [5], family history of diabetes [6-7], diabetes duration ≥ 5 years [2-4,7-10], insufficient glycemic control [5,10-11], no adherence to a healthy balanced diet [11], lack of exercise [12-13], overweight and obesity [9-14], mixed hypoglycemic therapies [15], type of insulin therapy [16], use of statins for any dyslipidemia [2,17], and hypertension [2-4, 9-11,16-19] are forecasting factors of complications from microvascular disease among T1DM and T2DM patients. The gene discussed is INS; the disease is type 1 diabetes mellitus.