Next, we assessed the transcriptome of genes of interest to Alzheimer’s disease and resistance (Arboleda-Velasquez et al., 2019; Lopera et al., 2023), APOE, APP, MAPT, PSEN1, and RELN and found no notable differences across cell lines (Supplementary Figure 4). Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.