Complementing these findings, the International Triadin Knockout Syndrome Registry has revealed that recessive null mutations in TRDN-encoded cardiac triadin contribute to severe arrhythmic conditions, including exercise-induced cardiac arrest in young children, which are refractory to conventional therapies and often necessitate implantable defibrillators due to recurrent ventricular arrhythmias (33). The gene discussed is TRDN; the disease is Ventricular arrhythmia.