Analogous results were reported in a French study in 311 patients with IDH-mutant anaplastic astrocytoma, in whom the 4-year PFS was 70.8% if treated with radiotherapy and PCV and only 53.5% if treated with radiotherapy and TMZ (HR 0.58[95% CI 0.38 to 0.87], p-value=0.0074) (164). Here, IDH1 is linked to anaplastic astrocytoma.