Concurrently, both in vitro and in vivo studies have demonstrated that resistin promotes the expression of VEGF-A and angiogenesis within the tumor microenvironment by inhibiting the expression of miR-5-3p through the PI3K/Akt signaling cascade, thus affecting tumor bone metastasis (146, 147) (Table 1). The gene discussed is RETN; the disease is neoplasm.