Additionally, Chemerin can upregulate pro-angiogenic factors such as VEGF-A, MMP-9, MMP-2, and S100A9 in neutrophils through the activation of the MEK/ERK signaling pathway (150, 184) (Table 1), thereby facilitating tumor vascularization and bone metastasis in lung cancer. This evidence concerns the gene RARRES2 and lung carcinoma.