Through bioinformatic analysis of TCGA (The Cancer Genome Atlas), GTEx (The Genotype-Tissue Expression), CCLE (Cancer Cell Line Encyclopedia), GSCA (Generalized Structured Component Analysis), CancerSEA (Cancer single-cell state atlas), and Cmap (Connectivity Map) databases, Wang and colleagues observed that PRKCSH expression showed an inverse relationship with the infiltration of M1 macrophages in six different cancer types. Here, PRKCSH is linked to cancer.