PDE6D and familial pancreatic carcinoma: As previously shown by our research group, the C14 and P8 compounds belong to the family of molecules that are able to specifically bind to and stabilize the mutated complex of K-Ras4Bmut/PDE6δ in G12C, G12V, and G12D K-Ras4B mutant pancreatic cell lines, disrupting its localization, activation, and inhibition of oncogenic Ras signaling in pancreatic cancer cells (33).