A variety of cells of the immune response release pro-inflammatory cytokines, including IL-1β, IL-1α, TNFα, IL-6, IL-12, IFN-γ, and chemokines such as CCL2 and CXCL12, which participate in the initiation, growth, and progression of tumor and development of drug resistance (8, 9). The gene discussed is IL6; the disease is neoplasm.