ZAP-70 induction in CLL B cells causes activation of specific BCR-signaling molecules, including SYK, BLNK, ERK, JNK, PLCγ, and AKT kinases (210, 211), indicating ZAP-70 promotes the growth and survival of the tumor cells by stimulating BCR signaling. Here, BCR is linked to B-cell chronic lymphocytic leukemia.