ELAVL1 and colitis: Interestingly, in a mouse model of LPS induced colitis and colorectal cancer, activated inflammatory tumor-activated macrophages from HuR-deficient mice showed increased expression of RNAs like TNF, TGF-β, IL10, Ccr2 and Ccl2. Overexpression of HuR in myeloid cells induced posttranscriptional silencing of these inflammatory cytokine mRNAs, thereby protecting mice from colon cancer development (177, 178).