CCL2 and IL-8, chemokines that suppress normal hematopoiesis, are increased in the BM microenvironment and tend to promote the capacity of BM stromal cells to support the adhesion of ALL cells, indicating that elevated levels of CCL2 and IL8 could indirectly confer survival advantage to ALL cells (142). Here, CXCL8 is linked to acute lymphoblastic leukemia.