Interestingly, in a mouse model of LPS induced colitis and colorectal cancer, activated inflammatory tumor-activated macrophages from HuR-deficient mice showed increased expression of RNAs like TNF, TGF-β, IL10, Ccr2 and Ccl2. Overexpression of HuR in myeloid cells induced posttranscriptional silencing of these inflammatory cytokine mRNAs, thereby protecting mice from colon cancer development (177, 178). The gene discussed is ELAVL1; the disease is colonic neoplasm.