For instance, a significant decreasein eGFR leads to reduced concentrations of uromodulin (also knownas Tamm–Horsfall glycoprotein), produced by renal tubules.Because uromodulin has bacteriostatic properties, its diminished presenceaffects bacterial growth.24 Therefore,CKD affects the diversity and composition of the bladder/urinary microbiota,subsequently influencing urinary tract symptoms and bladder health. This evidence concerns the gene UMOD and chronic kidney disease.