For women with anti-SSA/Ro52 autoantibodies, the risk of giving birth to a child with congenital heart block (CHB) has been reported to be 2%–3%.1–3 The recurrence rate if the woman already gave birth to a child with CHB is reported to 12%–25%.4–7 The cause of this condition is antibody-mediated inflammation, which affects the atrioventricular node (AVN) in the fetus. This evidence concerns the gene TRIM21 and congenital heart block.