Through the mutual mapping of drug target genes and disease target genes, combined with the PPI protein interaction network relationship for prediction, the results suggested that AKT1, TP53, FOS, MMP9, VEGFA, CASP3, and ADAR (1A, 1B, 2A, and 2C) may be the key core proteins for the treatment of lung cancer. The gene discussed is CASP3; the disease is lung cancer.