SOCS3 and hypertensive disorder: For the most significant CRP-CpG sites, SOCS3, TMEM49, and AIM2, the EWAS findings of hypomethylation in the Suppressor of Cytokine Signaling (SOCS) 3 gene is consistent with previous findings of SOCS3 as a negative regulator of IL-6 [43], including studies indicating hypomethylation associated with type-2 diabetes [44] and hypertension (specifically, right atrial pressure) [45].