Also, increased immunoreactivity of senescence markers p16, basic helix–loop–helix family member E40 (DEC1) and high mobility group box 1 (HMGB1) were shown, suggesting that EMT and senescence might intersect in the retina of dKO mice, contributing to an AMD‐like phenotype. This evidence concerns the gene HMGB1 and age-related macular degeneration.