Up-regulated in UF-EVs are predicted to modulate 2 pathways related with cancer, metabolic pathways, cellular processes (endocytosis and regulation of actin cytoskeleton), endocrine system (insulin signaling pathway) and signaling processes (MAPK, Ras, Wnt, Rap1 and mTOR) that control cell cycle, cell–cell junction formation and cell polarity, cytoskeletal organization, metabolism, and survival (Fig. 3B). Here, INS is linked to cancer.