miRNAs up-regulated in OF-EVs are predicted to modulate 5 pathways related with cancer, metabolism (purine metabolism), cellular processes (endocytosis), endocrine system (insulin signaling pathway), and signaling processes (AMPK, Ras, and Wnt) that regulate cell cycle, proliferation, survival, growth, migration, and differentiation (Fig. 3A). The gene discussed is INS; the disease is cancer.