INS and cancer: Exclusive miRNAs in UF-EVs are predicted to modulate 2 pathways related with cancer, metabolic pathways and pathways related with endocrine system (insulin signaling pathway), cellular processes (endocytosis, regulation of actin cytoskeleton and cell adhesion molecules) and signaling processes (MAPK, RAS, Wnt, Rap1 and Hippo) that modulate cell apoptosis, cell proliferation, differentiation, migration, among other cellular functions (Fig. 2B).