Considering only the 15 signaling pathways with the most significant P-values in each group as mainly modulated by those miRNAs, the ones exclusively found in OF-EVs are predicted to modulate 2 pathways related with cancer, endocrine system (insulin signaling pathway), cellular processes (endocytosis, focal adhesion, and tight junctions) and signaling processes (RAS and ErbB) that can regulate cell proliferation, differentiation, cell motility, and survival (Fig. 2A). The gene discussed is INS; the disease is cancer.