However, previous studies did not find its variants in 110 Algerian families and European descendants [9, 30, 31]; this may be due to that INAD (PLA2G6 ) was not classified as an ARCA in these previous studies as ataxia is not the main feature of this condition, therefore these patients were probably not recruited, which explain the absence of INAD patients in these cohorts. This evidence concerns the gene PLA2G6 and neurodegeneration with brain iron accumulation 2A.