Moreover, another research conducted by Chen et al. [41] found that Chaihu Shugan San (CSS) showed a therapeutic role in depressive-like rats exposed to CUMS and increased hippocampal neurogenesis, however, K252a fully attenuated the role of CSS, which verified that BDNF pathway was required for the neuronal proliferation, and revealed that promoting neurogenesis might be a potential strategy for treating depression in adult animals. Here, BDNF is linked to major depressive disorder.