CASP1 and early-onset autosomal dominant Alzheimer disease: It was reported that NLRP3 inflammasome consisted of three protein subunits, NLRP3, ASC and caspase-1 [20], the activity of NLRP3 inflammasome has been considered as one of the important factors in a variety of CNS diseases, such as Alzheimer’s disease and stroke [46, 47].