SMARCA2 and non-small cell lung carcinoma: To identify proteins potentially involved in the BM of NSCLC, we employed two NSCLC cell lines, PC9 (EGFRDexon19 mutation) and H2030 (K-rasG12C mutation) cells, to develop a high-brain metastatic subpopulation (PC9-BrM and H2030-BrM, Fig. 1A, Fig. S1A) and performed further proteomics analysis in PC9 and PC9-BrM cells to characterize the protein expression profile found in BM in our previous work[22, 23].