Venn diagram analysis revealed that seven DEGs (CXCL8, MLXIPL, CREB3L1, EGR1, NOTCH3, ACTA2, and SERPINE1) were associated with both obesity and diabetes-associated pathways, including non-alcoholic fatty liver disease, insulin resistance, thermogenesis, and apelin signaling pathways. The gene discussed is SERPINE1; the disease is Insulin resistance.