In univariate analysis after adjusting for age, sex, education, APOE ε4 carrier status, and clinical diagnosis, the apathy sub-syndromes showed correlation with CSF t-tau/ Aβ42 (estimate 0.372; 95% CI [0.278, 0.618]; P =0.044) and microbleed (estimate 0.695; 95% CI [0.041, 1.349]; P =0.037) (Table 6). The gene discussed is APOE; the disease is Apathy.