TP53 and neoplasm: Transplantation of two other KPC lines, 2838c3 and 6419c5, derived from GEMMs (PdxCre; Kras+/G12D; Trp53+/R172H; RosaYFP/YFP) that had been previously used to examine immune heterogeneity in the PDAC tumor microenvironment [36] led to similar high rates of primary tumor formation, but low rates of liver metastasis (Table 1).