Therefore, we chose the RF model as the best model for predicting LN occurrence, and screened the LN signature genes by RF, and YTHDC1, HNRNPA2B1, CBLL1, ZC3H13, IGFBP1, YTHDC2, and YTHDF2 were selected as candidate genes. The gene discussed is ZC3H13; the disease is lobular neoplasia.