Therefore, we chose the RF model as the best model for predicting LN occurrence, and screened the LN signature genes by RF, and YTHDC1, HNRNPA2B1, CBLL1, ZC3H13, IGFBP1, YTHDC2, and YTHDF2 were selected as candidate genes. This evidence concerns the gene IGFBP1 and lobular neoplasia.