MLKL and viral infectious disease: Taken together, we propose a mechanistic sequence for the acute-onset epileptic MIRAS form with valproate hepatotoxicity: (1) virus infection and the MIRAS-related aberrant immune response elicit an epileptic status through subacute loss of GABAergic cortical neurons; (2) the virus causes a subclinical inflammation also in the liver, priming the cells to necroptosis through increased MLKL phosphorylation.