The findings showed that various factors, including age, myocardial infarction, cerebrovascular disease, chronic kidney disease, liver disease, CCI, APSIII, mean blood pressure, heart rate, body temperature, SaO2, WBC, serum creatinine, BUN, sodium, potassium, calcium, chloride, eGFR, NT-proBNP, bicarbonate, hypochlorhydria, hypernatremia, use of diuretics and MV, were all linked to mortality during hospitalization (Table 2). The gene discussed is NPPB; the disease is chronic kidney disease.