Furthermore, the IHC staining data of clinical ESCC tissues from validation cohorts 1, 2, and 3 showed an intimate and positive correlation between the IHC scores of NR4A2 and those of SLC7A5, MAT2A, MAT2B, and METTL3, respectively (Fig. 7F–M). The gene discussed is SLC7A5; the disease is esophageal squamous cell carcinoma.