Furthermore, the IHC staining data of clinical ESCC tissues from validation cohorts 1, 2, and 3 showed an intimate and positive correlation between the IHC scores of NR4A2 and those of SLC7A5, MAT2A, MAT2B, and METTL3, respectively (Fig. 7F–M). Here, METTL3 is linked to esophageal squamous cell carcinoma.