Moreover, deletion of METTL3 in ESCC cells dramatically restrained methionine and SAM-elicited global RNA m6A methylation (Fig. 3G, H and Supplementary Fig. S6D, E) and attenuated NR4A2 expression at both the mRNA and protein levels (Fig. 5E). The gene discussed is NR4A2; the disease is esophageal squamous cell carcinoma.