METTL3 and esophageal squamous cell carcinoma: Reanalysis of the proteomic data from the discovery cohort of our previously published study [10] manifested a significant upregulation of three m6A writer enzymes, namely METTL3, METTL14, and METTL16, along with two cofactors, WTAP and RBM15B, in clinical ESCC tissues (Fig. 3F).