Markers associated with circulating neutrophils (Sellhi, CD62L; Cxcr4lo) were higher in clusters C1 and C2 while markers linked to increased effector function (Icam1), immunosuppression (Cd274+, PD-L1), and tumor-promotion (Siglecf) were higher in clusters C0 and C3; these expression patterns generally corresponded with treatment group (Fig. 5D, Supplementary Table S4) [36, 37]. Here, CD274 is linked to neoplasm.