ICAM1 and neoplasm: Tumor-associated neutrophils, characterized by an activated phenotype of CD62Llow (SELL)/CD54high (ICAM1) (comparable to our scRNA-seq clusters C0 and C3), have high rates of phagocytosis and ROS production, and can directly induce cytokine production in activated T cells [58], which our data suggests could occur through either CD80 or IL-23 expressed by the neutrophils.