EGFR and glioblastoma: Unexpectedly, EGFR-KO did not impact the proliferation of MES-GSC cells in complete growth media in vitro (Fig. 3d) suggesting that oncogenic EGFR is not essential for intrinsic control of growth and survival of these cells, but instead may possess non-cell-autonomous functions in GBM, at least in part, mediated by its EV-mediated export.