A quantitative comparison of transcripts associated with large vessels from EGFR-WT tumours (vasectasia) versus small vessels from EGFR-KO tumours (angiogenesis), as depicted in the volcano plot (Supplementary Fig. 9e), demonstrated several significant differences (>2 fold; p < 0.05) with large vessels microregions being enriched for Cd99, Pcbd2 and Ripply2 relative to small vessel microregions. The gene discussed is PCBD2; the disease is neoplasm.