Moreover, one of our suggested candidates for manic episodes, ESR2, and one for substance use disorder, BTN3A2, were previously associated at the gene-level with major depression in the large GWAS, while one of our candidates for hypomanic episodes and alcohol dependence, the BP-associated RIMS1 [26], mapped previously to schizophrenia loci. This evidence concerns the gene ESR2 and manic or hypomanic episode.