Previous studies have demonstrated that Angiotensin II may accelerates the development of atherosclerosis in ApoE-KO47,48, increasing atherosclerotic lesions with a vulnerable phenotype by activation of MMP8 and MMP1349 and forming aneurysms in the aorta, without changing hemodynamics47 Therefore, it is important to investigate the impacts of aging and exercise training on level of Angiotensin II and the cardiovascular repercussions on Apoe-KO female in future studies. This evidence concerns the gene MMP8 and atherosclerosis.