It is worth mentioning that the deficit of ApoE generates a series of organic changes, such as imbalance in cholesterol metabolism, systemic inflammation, increased production of reactive oxygen species, reduced expression of antioxidant genes, increased demand for renin-angiotensin system and degradation of the extracellular matrix5 which may have contributed to the process of dysautonomia and vascular damage. The gene discussed is REN; the disease is dysautonomia.