MAPT and Alzheimer disease: Post-mortem studies have demonstrated that DLB patients with high Braak neurofibrillary tangle (NFT) tau stages exhibit more severe atrophy in stereotypical AD regions, such as the temporoparietal cortices, hippocampus, and amygdala6–8, and these findings have since been corroborated by in vivo positron emission tomography (PET) imaging studies9–12.