MAPT and Neurofibrillary tangles: In comparison to FA, additional tracts where tau was associated with elevated MD and reduced tNDI involved the ventral limbic projections and inferior temporal white matter projections, all of which are known to have dense projections within the “cortical neurodegeneration signature” of AD32, a select group of regions that are susceptible to early neurofibrillary tangle accrual in AD33–35.