KMT2D and diffuse large B-cell lymphoma: To further explore the nature of CREBBP and KMT2D cooperation in human lymphoma cells, we generated several isogenic clones of the GCB-DLBCL cell line OCI-Ly7 as follows: CREBBPR1446C (C, a HAT inactivating mutation often found in human lymphomas), CREBBP-KO (CKO), KMT2D-KO (K), CREBBPR1446C + KMT2D-KO (CK), as well as CRISPR non-edited control clones (WT) (Supplementary Fig. 6a–e).