To better understand how loss of CREBBP and KMT2D set the stage for lymphoma formation with the observed phenotypes, we generated mice with the following genotypes: Cγ1cre/+, Cγ1cre/+;Crebbpfl/+, Cγ1cre/+;Kmt2dfl/+, and Cγ1cre/+;Crebbpfl/+;Kmt2dfl/+, hereafter referred to as WT, C, K, and CK respectively. This evidence concerns the gene KMT2D and lymphoma.