Li et al. investigated the changes in sensitivity to mitogen-activated protein kinase inhibitors during breast cancer progression; they used the MCF10 cell line series and compared the results between 2D and 3D culture models.209 They found the results between these two models to be discordant, with increased sensitivity to these inhibitors in the 3D than in the 2D model. This evidence concerns the gene WNK2 and breast carcinoma.