Pertuzumab, another humanized anti-HER2 monoclonal antibody, with a distinct binding site from trastuzumab, prevents the heterodimerization of HER2 with HER1, HER3, and HER4, ultimately leading to the attenuation of intracellular HER2 signaling.359,360 Clinical trials have demonstrated noteworthy outcomes by combining these two monoclonal antibodies with chemotherapy for the treatment of HER2-positive breast cancer. The gene discussed is EGFR; the disease is breast carcinoma.