They further observed a significant decrease of p63 + TCF7+ MECs in MCF10DCIS models compared to normal MECs which correlate with invasive progression.152 Thus, the downregulation of tumor suppressor markers and upregulation of pro-invasive markers in DCIS-associated MECs indicate the possibility of achievement of an invasive phenotype, despite the presence of morphological similarities with normal MECs. The gene discussed is TCF7; the disease is ductal breast carcinoma in situ.