HSF1 and amyotrophic lateral sclerosis: There is increasing appreciation for epigenetic mechanisms contributing to ALS and other neurodegenerative disorders including DNA methylation, chromatin remodeling factors, and post-translational modification of histones.3, 16, 49, 50, 51 Recruitment of chromatin remodeling complexes by HSF1 is an important aspect of transcriptional regulation52; thus, the loss of nBAF chromatin remodeling complexes in ALS might be disruptive.