Like emerin, lamin A/C and SUN1/2 proteins, mutations in either nesprin-1 or -2 are causative in autosomal dominant Emery–Dreifuss muscular dystrophy (EDMD) with heart conduction defects (CD) and dilated cardiomyopathy (DCM) (2). This evidence concerns the gene SYNE1 and Emery-Dreifuss muscular dystrophy.