An R153H mutation, close to the two phosphorylation sites (amino acid 157 and 161) of telethonin, was identified at the C-terminal region of telethonin in hypertrophic cardiomyopathy (HCM) patient (18), and an R113C mutation in the nesprin-2 binding region was identified in the LIM-2 domain of FHL-2 in an EDMD patient with conduction defect (Fig. S5). This evidence concerns the gene SYNE2 and hypertrophic cardiomyopathy.