Like emerin, lamin A/C and SUN1/2 proteins, mutations in either nesprin-1 or -2 are causative in autosomal dominant Emery–Dreifuss muscular dystrophy (EDMD) with heart conduction defects (CD) and dilated cardiomyopathy (DCM) (2). Here, SYNE1 is linked to dilated cardiomyopathy.