A base model combining age, sex, WMHV, education, childhood cognition, socioeconomic position and APOE genotype, provided an AUC for Aβ-positivity of 0.73 (95% CI 0.66 to 0.81) and predictive ability was not significantly improved by inclusion of hearing impairment (AUC 0.76, 95% CI 0.69 to 0.83) or PTA (AUC 0.75, 95% CI 0.68 to 0.82). The gene discussed is APOE; the disease is hearing loss disorder.