,167 AML patient-derived hiPSCs bearing a KMT2A-MLLT3 fusion146,166 were differentiated into HLF+ HOXA+ hematopoietic progenitors; these could robustly engraft NOD-SCID Il2rg−/− (NSG) mice and yielded almost exclusively myeloid cells in vivo (Figure S7F). The gene discussed is IL2RG; the disease is acute myeloid leukemia.