NRSN2 and osteosarcoma: Neurensin-2 (NRSN2), a protein localized on the cell membranes, has been reported to perform a cancer-promoting role in a variety of tumors in recent years.21 For example, studies have found that high NRSN2 expression is associated with the malignant phenotype of ovarian cancer.22 The report of Keremu A et al.23 revealed that NRSN2 promotes the growth of osteosarcoma cells.