CD4 and neoplasm: Extracellular vesicles (EV) produced by APOE‐deficient animals can enhance the gene expression of inflammatory cytokines and M1 macrophage markers, while decreasing the gene expression of M2 macrophage markers, stimulating the growth of CD4+ T cells and triggering the production of IFN‐γ in T cells.[33] It has been previously reported that the spatial distance between immune cells in the tumor microenvironment affects patient biological events.