found that CD8+ T cells in tumors would be presented with antigens by tumor‐associated macrophages (TAMs) expressing IRF8 to promote T cell depletion.[18] Previous studies have mainly explored the relationship between macrophage‐related genes, the TME and immunotherapy effects,[19] whereas few have combined pan‐cancer scRNA‐seq with machine learning algorithms to explore the correlation between macrophage subpopulations and T cells that effecting immunotherapy response. Here, CD8A is linked to cancer.