It has been verified in a previous study on hepatocellular carcinoma,[30] revealing that FOLR2+ macrophages express high levels of immunomodulatory chemokines (such as CXCL12 and CXCL16) and are located around the blood vessels of tumor immune privileged sites; thus, they play a major role in immunosuppressive interactions. This evidence concerns the gene CXCL12 and neoplasm.