Among these splicing regulators, SRSF1, serving as the archetype member of the SR protein family,[14] has the capability to modulate AS isoform generation by binding to specific RNA sequences and influencing spliceosome activity.[15] While SRSF1 is recognized for its involvement in various biological processes and diseases, including the cell cycle, apoptosis, adipocyte differentiation, stress response, cancer, and neurodegeneration,[16] its precise function in mature adipocytes still lacks clarity. This evidence concerns the gene SRSF1 and cancer.