Emerging evidence underscores the significance of mutations or altered expression patterns in splicing regulators, along with aberrant splicing events, as common factors in diet‐induced obesity and metabolic dysregulation.[23] Among these regulators, SRSF1 assumes a pivotal role as a splicing factor that governs AS in numerous genes crucial for essential cellular functions.[24] However, its contribution to brown adipocyte thermogenesis and white adipocyte browning, two critical physiological processes tightly linked to energy expenditure, remains largely unexplored. This evidence concerns the gene SRSF1 and Obesity.