INS and type 2 diabetes mellitus: Recent evidence indicates a satisfactory validity of METS-IR against the adjusted whole-body glucose disposal rate (ie, M value) derived from the “gold standard” HEC and the reliability of METS-IR when compared to both fasting insulin-based indexes (eg, homeostatic model assessment for IR and quantitative insulin sensitivity check index) and noninsulin-based indexes (eg, triglyceride-glucose index, triglyceride-glucose-BMI index, and triglyceride/HDL-C ratio) for predicting T2DM in a Mexican outpatient cohort [14].