However, this variant infection induced a lower amount of Interleukin 1β (IL-1β) and macrophage inflammatory protein-1α (MIP-1α) compared to the wild-type (Fig 4d and 4m), In the other hand, the Alpha variant triggered a considerable level of TNF-α (14.73 pg/mL) and a modest rise of IP-10 level than wild type (Fig 4a and 4b). This evidence concerns the gene TNF and infection.