Although the current work focused on differences in HCN channel activity, we know that CaV3 channels and two-pore domain potassium (K2P) channels (e.g., TASK and TREK) allow thalamocortical neurons to switch between burst firing and tonic action potential generation in different behavioral states such as sleep and wakefulness (40, 41) and are linked to epilepsy and neurodevelopmental disorders (42–45). The gene discussed is KCNK3; the disease is epilepsy.