MAPT and Alzheimer disease: The two main Alzheimer’s disease neuropathological changes (ADNC)—amyloid-β (Aβ) plaques and phospho-tau (pTau) neurofibrillary tangles—are closely surrounded and/or penetrated by reactive astrocytes and microglia [25, 44, 45], yet the role of these glial responses in the formation, maturation, and clearance of ADNC and in downstream neuronal and synaptic loss remains controversial [38].