We found significantly higher MAO-B expression in AD (high ADNC burden) than in CTRL (not AD/low ADNC burden) in temporal cortex and white matter, frontal cortex and white matter, and occipital cortex, whereas MAO-B+ area fraction did not significantly differ across ADNC groups in occipital white matter, cerebellar cortex, and cerebellar white matter (Fig. 4). This evidence concerns the gene MAOB and Alzheimer disease.