To inform future MAO-B-based PET imaging studies in ADRD, it will be important to investigate possible correlations between MAO-B area fraction and both the local burden of protein aggregates (α-synuclein, pTau, and pTDP-43 in LBD, FTLD-Tau, and FTLD-TDP, respectively) and the severity of cortical atrophy in postmortem brains of donors with these primary neuropathological diagnoses. This evidence concerns the gene MAOB and Cerebral cortical atrophy.