A similar analysis for patients with PVs in BRCA2 revealed statistically significant differences in gene expression in 10 of the 16 cancer genes, and in 3 gene group scores, all in a direction that contributed to higher RS results in the study patients (lower expression in study group patients vs the CDB in PGR, GSTM1, BAG1, and the ER gene group score; higher expression in CCNB1, KI67, STK15, SURV, MYBL2, GRB7, and CTSL2, and the HER2 and the proliferation gene group scores) (Table 2). Here, ESR1 is linked to cancer.