ESR1 and cancer: The cancer-related genes include 4 linked to the estrogen-signaling pathway (ESR1, PGR, BCL2, and SCUBE2), 5 to proliferation/anti-apoptosis (CCNB1, KI67, STK15, SURV, and MYBL2), 2 to the HER2 pathway (ERBB2 and GRB7), 2 to invasion (STMY3 and CTSL2), and 3 (CD68, GSTM1, and BAG1) to macrophage function, detoxification, and apoptosis, respectively.