The obtained results illustrated that Da-PFC-NPs significantly up-regulated of caspase 3 gene and down-regulated the HER2 gene expression (Fig. 8). Similar to the observation made in this study, Moeini et al. [21] reported the apoptotic activities of nanophytosome‐loaded phenolic compounds from fruit of Juniperus polycarpos against breast cancer in mice model. Here, CASP3 is linked to breast carcinoma.