As the incidence is in decline, its frequency among all forms of amyloidosis is being replaced by other types such as immunoglobulin light chain (AL) and transthyretin amyloidosis [2], and a recent proteomics study involving 16,175 samples revealed that only 2.9% of all cases suffered from AA amyloidosis [5, 6••]. The gene discussed is TTR; the disease is amyloidosis.