After adjusting for age, sex, APACHE II score, diabetes, use of glucocorticoid in hospital and use of insulin in hospital, only TARs with a glucose threshold of 10.5 mmol/l (190 mg/dl) or higher (TAR>10.5 to TAR>13.9) were significantly associated with in-hospital mortality risk (Table 2, Fig. 1). This evidence concerns the gene INS and diabetes mellitus.