Frailty has been linked to endothelial dysfunction,8 evidenced by increases in key markers: adhesion intercellular molecule 1 (ICAM‐1),78, 84 endothelin‐1,85 Von Willebrand factor (VWF),86 thrombomodulin,87 ADMA,8 IL‐688 and c‐reactive protein.89 The gene discussed is ICAM1; the disease is endothelial dysfunction.