Endothelial injury in rats and RhoA/Rho kinase activation in stress‐treated EC cultures are associated with increased levels of biomarkers found in frail human adults, such as ADMA, endothelin 1 and 8‐isoprostane, suggesting a possible implication of the RhoA/Rho kinase pathway in the endothelial dysfunction occurring in frailty.15, 16, 17. The gene discussed is RHOA; the disease is endothelial dysfunction.