RENBP and COVID-19: While the need for confirmatory testing in settings of low disease prevalence is not a novel concept to epidemiologists or diagnostic laboratories for SARS-CoV-2 (20, 21) or other microorganisms (22, 23), mass asymptomatic population testing for SARS-CoV-2 using Ag-RDTs during the COVID-19 pandemic provided an excellent opportunity to demonstrated how an NAE-free RT-PCR (i.e., the Taqman PACMAN) was a simple solution for positive Ag-RDT confirmation during periods of high testing volumes, low prevalence, and competing laboratory testing priorities.